Genotoxic and cytotoxic metabolites are formed by each of these pathways. 4. (Grant and Hackh's Chemical Dictionary, 5th ed). If dams were exposed on day 17 of pregnancy, levels in the fetal brain were lower than in other organs. Both volatile (unchanged compound) and non-volatile (metabolite) radioactivity reached embryonic and fetal tissue, particularly the liver and blood. As a result, tetrachloroethylene can also be persistent in the water because it has a higher density than water and relatively low water solubility. Tetrachloroethene is a manufactured chemical that is widely used in the dry-cleaning of fabrics, including clothes. Packaging 1, 2 L in Sure/Seal™ 100 mL in Sure/Seal™ Degradation products observed in a laboratory include phosgene, trichloroacetyl chloride, hydrogen chloride, carbon dioxide, and carbon monoxide. During hyperventilation therapy, the relative contribution to the fast elimination process increased from 70% for physiological minute volume to 99.9%. Handbook of Veterinary Drugs. The elimination of tetrachloroethylene in expired air ranged from 50 to 150 ppm (339 to 1,017 mg/cu m) for up to 8 hr. Images of the chemical structure of TETRACHLOROETHYLENE are given below: The 2D chemical structure image of TETRACHLOROETHYLENE is also called skeletal formula, which is the standard notation for organic … Volumes 1: New York, NY. Several other minor metabolites have been found, including oxalic acid, dichloroacetic acid, ethylene glycol, trichloroacetyl amide, trichloroacetylaminoethanol, thioethers, and carbon dioxide. Tetrachloroethylene, also called perchloroethylene, a colourless, dense, nonflammable, highly stable liquid belonging to the family of organic halogen compounds.Tetrachloroethylene is a powerful solvent for many organic substances. 1.4 Uses Tetrachloroethylene is mainly used as a solvent in dry cleaning and metal cleaning. Similarly, VOCs shifted the half-maximal voltage of steady-state inactivation (V1/2, inact) from approximately -16 mV in control to -32, -35, and -20 mV in the presence of TOL, TCE, and PERC, respectively. It is also used for processing and finishing in the textile industry, as an extraction solvent, veterinary anthelmintic, heat-exchange fluid, grain fumigant, and in the manufacture of fluorocarbons. Tetrachloroethylene is used as a dry cleaning agent and a solvent to degrease metals. International Programme on Chemical Safety's Concise International Chemical Assessment Documents. The TCVC derivatives are toxicologically important but quantitatively minor metabolites. It is a clear, colourless non-flammable liquid with a chloroform-like sweet smell. Chiu WA et al; Toxicol Sci 95 (1): 23-36 (2007). Mass-balance studies in rats with 14C-labeled tetrachloroethylene indicated that 70% or more of an oral or inhaled dose can be recovered in expired air as the parent compound. Trichloroethylene (TRI) and tetrachloroethylene (TETRA) are solvents that have been widely used in a variety of industries, and both are widespread environmental contaminants. Substances that increase the risk of NEOPLASMS in humans or animals. Uses. It should not be confused with the similar 1,1,1-trichloroethane, which is commonly known as … For TRI, data from the current study support lower apparent blood-air partition coefficients, greater apparent metabolic clearance, less TCA production, and greater glucuronidation of TCOH as compared to previous studies. •Evaporates when exposed to air. World Health Organization. Tetrachloroethylene [un1897] [poison], 130. Exposure to this substance irritates the upper respiratory tract and eyes and causes neurological effects as well as kidney and liver damage. A 10-min inhalation exposure of pregnant mice to 14C-radiolabelled tetrachloroethene /resulted in/ a high uptake of radioactivity in the maternal body fat, brain, nasal mucosa, blood, and well perfused organs such as liver, kidney, and lung. Structure, properties, spectra, suppliers and links for: Tetrachloroethylene, perchloroethylene, Tetrachloroethene, 127-18-4. Differences as high as 20% were often found in the physiological parameters, including differences in average body weight, tissue volumes, and blood flows. U.S. Dept Health & Human Services/Agency for Toxic Substances & Disease Registry; Toxicological Profile for Number 18: Tetrachloroethylene p. 97-98 (September 1997). [] Tetrachloroethylene is a colourless, volatile liquid with an ether-like odour. 2. Number 68: Tetrachloroethene (127-18-4). /Former/, VET: Restrict dietary fat within 2 days before and after use to avoid enhanced absorption of this fat sol liver toxicant. 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